Sally Letter Adebamowo, Donna Spiegelman, Walter C Willett, Kathryn M Rexrode, Connection anywhere between intakes of magnesium, potassium, and you will calcium and chance of heart attack: 2 cohorts of us people and upgraded meta-analyses, This new American Record out-of Health-related Nutrition, Frequency 101, Thing 6, , Users 1269–1277,
Abstract
Background: Potential studies to your family members regarding magnesium, potassium, and you may calcium consumption which have coronary attack chance are contradictory, also to the knowledge, the outcome from a blended nutrient diet score wasn’t checked out.
Objective: I examined connectivity between consumption of magnesium, potassium, and you will calcium supplements and threat of incident stroke during the 86,149 women in the fresh new Nurses’ Fitness Data (NHS) I and you may 94,715 women in the new NHS II.
Design: In this potential cohort study, we determined Hours out of coronary arrest from the quintiles out-of consumption for each mineral as well as for a mixed diet get of the many 3 nutrients by using multivariate Cox proportional possibility designs. Simultaneously, we upgraded meta-analyses into diet intakes of them minerals and you will danger of coronary arrest.
Results: During the follow-right up (31 y on the NHS I; twenty-two y throughout the NHS II) a maximum of 3780 event stroke times had been documented. Pooled multivariate RRs out of full heart attack for ladies about high in contrast to the lowest quintiles had been 0.87 (95% CI: 0.78, 0.97) for complete magnesium, 0.89 (95% CI: 0.80, 0.99) having overall potassium, and you will 0.97 (95% CI: 0.87, step one.09) to possess total calcium supplements consumption. Pooled RRs for ladies in the high in contrast to a reduced quintiles out-of a blended nutrient eating plan score was basically 0.72 (95% CI: 0.65, 0.81) getting overall coronary arrest, 0.78 (95% CI: 0.66, 0.92) having ischemic coronary attack, and you may 0.80 (95% CI: 0.61, step 1.04) to possess hemorrhagic stroke. From the current meta-analyses of all potential degree so far, the fresh mutual RR out of overall heart attack try 0.87 (95% CI: 0.83, 0.92) having a hundred-mg/d escalation in magnesium consumption, 0.91 (95% CI: 0.88, 0.94) to have a a thousand-mg/d boost in potassium intake, and you will 0.98 (95% CI: 0.94, step one.02) for a 300-mg/d boost in calcium consumption.
Conclusions: A combined nutrient eating plan rating are inversely for the danger of coronary arrest. Large consumption off magnesium and potassium yet not calcium supplements was in fact plus rather for the shorter chance of heart attack in females.
Addition
Magnesium is an essential nutrient and cofactor getting >3 hundred enzymatic reactions in your body ( 1). Magnesium is the second extremely-plentiful intracellular cation next to potassium ( 2). Calcium is one of-plentiful nutrient within the body. Like magnesium and potassium, calcium is actually vitally involved in aerobic properties ( 3). Large slimming down consumption of each and every of these minerals was basically reported so you can straight down chance of blood pressure level ( 4– 7), which is the dominating modifiable stroke exposure foundation. But not, not absolutely all possible training checked this new family members between fat loss and you will extra intakes of these nutrition and you can risk of stroke in women, and you will abilities was indeed contradictory. Prospective education inside European countries showed magnesium intake, although not consumption out of potassium otherwise calcium supplements, is actually somewhat of the reduced danger of coronary attack ( seven, 8). Sikh dating In the us, consumption off potassium and you will magnesium, although not out-of calcium, were on the smaller heart attack chance within the men ( 9), while calcium and potassium intakes, not magnesium intake, was in fact of smaller stroke risk in women ( 10). Plus, you to investigation showed zero complete connection anywhere between some of these nutrients and you can chance of coronary arrest ( 11).
The possible observational degree that were held don’t were follow-upwards beyond fifteen y along with a relatively small number of incident stroke situations, plus extremely training, the new independent effect of for each mineral consumption off supplements and you can heart attack types wasn’t checked out. On this page, we provide facts into relationship of every mineral intake out-of diet and tablets that have danger of complete, ischemic, and you may hemorrhagic experience strokes. While doing so, i hypothesized one a combined diet plan get of all the step three minerals is generally associated with quicker stroke chance because these vitamins occur along with her in ingredients, and you may consumption is actually firmly correlated. I managed this type of seeks into the You women who have been accompanied prospectively on 2 large cohorts the newest Nurses’ Fitness Studies (NHS) 5 We and you can II.